The blind prophet of Thebes, Tiresias was the high priest of Apollo. When he revealed to King Oedipus that his majesty himself killed his father and married his mother, Oedipus gouged out his eyes and exiled himself. Oedipus' son, Eteocles, refused to share the throne with his brother, Polynices. During the invasion of The Seven Against Thebes, Tireseas foretold that the voluntary death of a Theban would save the city. The vision came true when Eteocles and Polynices died, each killed by the other. When Oedipus' brother, Creon, became king of Thebes, he decrees that the corpse of Polynices be left to decay. Oedipus' daughter, Antigone, was then outraged and is caught trying to bury her brother. So Zeus and Athena had Tireseas speak in their stead. Tireseas said to Creon that "The city is sick through your fault." Tireseas was then killed by Apollo because he drank from a cursed spring.
Shorlty after, Odysseus had arrived into the Underworld searching for his advice. Tireseas told Odysseus that Poseidon would not forgive him for blinding his son, Polyphemus the Cyclops, and that when he reached the Island of Helios that he must not eat any of the sheep or the cattle on the island (although Eurylochus, Odysseus' cousin, ignored this advice). Tireseas then warned Odysseus about the suitors that were after his blood and the blood of his son, Telemachus. Tireseas knew that Odysseus would slay them all, then the old priest told the King of Ithaca that he must journey to a land where no mortal has gone before. When the inhabitants of the land called Odysseus' oar a "winnowing shovel" Tireseas instructed him to place it in the ground as a sacrifice to appease Poseidon and then, and only then would he return to Ithaca. Tireseas is now in the Circle of Fraud. He changed himself from a man to a woman, indulging in the pleasures of both.
- In The Inferno, Dante and Virgil behold the shade of Tiresias in the fourth pit of the Malebolge, damned for his prophetic acts.