In Dante's Inferno, the player can adjust the difficulty to one of four settings. This makes the game easier or harder, but has no effect on anything else in the game. These can be accessed in the start menu.
- Classic - The minions of hell will cower in fear before you.
- Zealot - The minions of hell will pose a threat to you, but ultimately cannot withstand you.
- Hellish - The minions of hell will pose a threat to you, but there is a chance to survive.
- Infernal - You are damned.