The City of Dis is the infernal city that makes up the sixth circle of Hell, and the lower circles below. Inside Heresy are heretics and pagans who lie in fiery tombs. Throughout the city are Dark Priests who worship their dark god. Dante reaches the gates of the city by controlling the boatman Phlegyas, and uses his great strength to smash down the gates of the city. Once inside, Dante must battle his way through the fiery tombs and corridors of the hellish fortress, if he is to reach the seventh circle beyond.
- In "The Inferno", Dante and Virgil arrive at the gates of the City of Dis after crossing the fifth circle. The walls of the city encompassed the sixth circle of Hell, and all other circles then below. The gates are guarded by Fallen Angels, the Furies and Medusa who threaten Dante, who is protected by Virgil.
- The quote that Dante makes while moving towards the City of Dis is modeled after the narrative in Canto IX of the original poem.