Acre is the first level of Dante's Inferno and is the only level the player uses the Halberd. While in Acre, Dante and Francesco watch over civilian prisoners that are being held prisoner under the order of King Richard. During an attack on Acre, many prisoners escape and Dante is forced to kill them all. After killing several, a boat crashes into the area where Dante is, allowing him to advance into the Citadel of Acre. Here, Dante is assassinated and encounters Death. This level is complete once the player has defeated Death and taken his Scythe. Both Francesco and Dante die while in Acre.
- The opening level of the game is loosely based upon the historical Massacre at Acre during the Third Crusade in 1191. Nearly a month after Acre surrendered to the Crusaders, negotiations between Richard I and Saladin for the release of the prisoners broke down, and Richard ordered the execution of the 2,700 to 3,000 soldiers of the garrison that had surrendered to the Crusaders. In response, Saladin executed all the Christian prisoners in his possession. This event made the Seige of Acre one of the bloodiest events of the Third Crusade.